Ask the Rheumatologist: Latest Answer
Sherry from Calgary asks: I was just diagnosed with Rheumatoid Arthritis. I was prescribed methotrexate and hydroxychloroquine. I am currently in a flare so need to continue with diclofenac to control the pain. Is this drug combination safe?
There are animal based studies that suggest a concern about using methotrexate and any anti-inflammatory, including diclofenac, together. However, this combination is used commonly in patients with rheumatoid arthritis without any significant concerns. It is an appropriate way to control symptoms while waiting for the disease modifying agents, such as methotrexate and hydroxychloroquine, to start working. While all these medications have potential side effects, there are no significant increased risks when used together.