Karen from Canada asks: Can I use acetaminophen (Tylenol) with Methotrexate?

Assuming no other medical problems, there is no concern using acetaminophen when you are also taking methotrexate.  As long as you are not taking more than the maximum dose, and doing the bloodwork monitoring suggested by your rheumatologist, there is little risk to take both.  However, if you need acetaminophen, you should discuss this with your rheumatology team to ensure your pain is not a result of active inflammation, in which case, there may be other medication options which are more appropriate for the situation.

Posted: January 13, 2025

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