Dallas from Edmonton asks: My fiancée and I are getting married in less than a month and we have starting talking about having a family. I’m currently taking Methotrexate injections once a week. We are worried that the methotrexate could increase the chance of birth defects. Has there been any studies done regarding the effects of methotrexate in men when trying to have a baby?

Certainly females should not get pregnant while on methotrexate, with recommendations suggesting that women should stop methotrexate at least 3 months before trying to become pregnant.  The data for men is less clear.  There are rheumatologists who recommend the same for men, avoidance of methotrexate for at least 3 months before trying to conceive.  There are suggestions that methotrexate could affect sperm, however, no study has clearly shown any harmful effects.

Posted: October 13, 2015

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