Dallas from Edmonton asks: My fiancée and I are getting married in less than a month and we have starting talking about having a family. I’m currently taking Methotrexate injections once a week. We are worried that the methotrexate could increase the chance of birth defects. Has there been any studies done regarding the effects of methotrexate in men when trying to have a baby?

Certainly females should not get pregnant while on methotrexate, with recommendations suggesting that women should stop methotrexate at least 3 months before trying to become pregnant.  The data for men is less clear.  There are rheumatologists who recommend the same for men, avoidance of methotrexate for at least 3 months before trying to conceive.  There are suggestions that methotrexate could affect sperm, however, no study has clearly shown any harmful effects.

Posted: October 13, 2015

Tagged: , ,

← Browse More Answers



What is Rheumatology?

Rheumatologists see over 100 different types of diseases. We are known for seeing arthritis, however, we also see many other conditions.

Learn More

Find us on YouTube

Visit our YouTube channel and find a number of helpful videos to learn more about a range of topics relating to rheumatology.

Visit our YouTube Channel

Make a Donation

Support arthritis care in Alberta. Click the button below for more info, or to make a donation today.

Donate